BioE PhD Proposal Presentation- Srujana Joshi
Advisors: Dr. Lakshmi Prasad Dasi, PhD (Georgia Institute of Technology)
Dr. Holly Bauser-Heaton, MD, PhD (Emory University)
Committee: Dr. Rudolph Gleason, PhD (Georgia Institute of Technology)
Dr. Scott Hollister, PhD (Georgia Institute of Technology)
Dr. Susan James, PhD (Colorado State University)
Dr. Vinod Thourani, MD (Piedmont Healthcare)
Investigation of a Transcatheter Bio-Inspired Polymeric Valve for Hemodynamic Performance and Durability
With the recent Food and Drug Administration (FDA) approval extending transcatheter aortic valve replacement (TAVR) to intermediate and low risk patients with aortic stenosis, the procedure’s landscape has evolved significantly to include patients under 65. However, current technology drawbacks limit the use of TAVR in younger patients and complex anatomies such as bicuspid aortic valve, thereby limiting the full potential and benefits offered by the TAVR method. Existing devices use animal-tissue leaflets, which present durability challenges due to calcification, structural valve degeneration, and issues like leaflet thrombosis and paravalvular leakage (PVL). These complications reduce device lifespan and impair hemodynamic performance, often requiring reinterventions. Thus, for TAVR to become a long-term solution for younger patients, the next generation of devices must overcome these limitations. This includes development of devices with durable, biocompatible materials that are designed for excellent hemodynamic performance.Towards this goal, this project is aimed at developing a bio-inspired polymeric TAVR that is biocompatible and is designed for excellent hemodynamic performance and durability. The overall hypothesis is that the polymeric TAVR will have superior hemodynamic performance and durability than commercially available bioprosthetic TAVRs. A comprehensive focus on its pressure and flow performance coupled with durability will inform further improvements to its design and assembly, enhancing the device. This polymeric TAVR will pave the way for a long-lasting and biocompatible TAVR suitable for younger patients. The hypothesis will be tested through the following specific aims: 1) Compare hemodynamics of polymeric TAVR with standard bioprosthetic TAVR, 2) Investigate the efficacy of a dynamic seal for preventing paravalvular leakage and 3) Evaluate the role of manufacturing and deployment on polymeric TAVR durability.
By addressing the critical challenges of hemodynamic performance and durability, this work will contribute to the development of innovative TAVR solutions that meet the growing demand for more resilient, long-lasting valves in younger and high-risk patient populations.