Pharmaceuticals & Drug Delivery

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance.

Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection or a nanoneedle array.

For example, many immunizations are based on the delivery of protein drugs and are often done by injection. Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.

Assistant Professor
Research Interests: Our lab studies the response of bacteria to antibiotics in order to develop new methods for eradicating persistent bacteria.  Bacterial persistence is a form antibiotic resistance in which a transient fraction of bacterial cells tolerates severe antibiotic treatment while the majority of the population is eliminated. These ‘persisters’ can contribute to chronic infections and are a major medical problem. Despite their medical and scientific importance, presistence is not fully understood. A crucial challenge in studying bacterial persistence results from a lack of methods to isolate persisters from the heterogeneous populations in which they occur. As a result, systems-level analysis of persisters is beyond current techniques, and fundamental questions regarding their physiological diversity remain unanswered. Our lab seeks to develop methods to isolate persisters and study them with systems-wide, molecular techniques.  The resulting findings will be used to engineer improved antibiotic therapies.  Dr. Allison’s previous research included development of a novel method to eradicate pathogenic bacteria, including Escherichia coli and Staphylococcus aureus, by metabolic stimulation and the finding that bacteria communicate with each other to alter their tolerance to antibiotics.
Research Areas:
Neuroengineering, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Interests:

Therapeutic applications of ultrasound: Costas Arvanitis’ research investigates the therapeutic applications of ultrasound with an emphasis on brain cancer, and central nervous system disease and disorders. His research is focused on understanding the biological effects of ultrasound and acoustically induced microbubble oscillations (acoustic cavitation) and using them to study complex biological systems, such as the neurovascular network and the tumor microenvironment, with the goal of developing novel therapies for the treatment of cancer and central nervous system diseases and disorders.

Research Areas:
BioImaging, Biomechanics, Neuroengineering, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Interests:

The Blazeck Lab tackles challenges at the interface of immunology, engineering, and metabolism to improve human health. We utilize our expertise in cellular and protein engineering to control biological function and to develop novel therapies to fight disease.

Research Areas:
Pharmaceuticals & Drug Delivery, Systems Biology
Adjunct Professor
Research Interests:

Water and wastewater microbiology Bioaerosols Antimicrobial resistance in the environment Engineering applications in underserved communities

Research Areas:
Pharmaceuticals & Drug Delivery
Associate Professor
Research Interests:

Developing therapeutic protein materials, where the protein is both the drug and the delivery system Engineering proteins to control and understand protein particle self-assembly Repurposing and engineering pathogenic proteins for human therapeutics Creating materials that mimic cell-cell interactions to modulate immunological functions for various applications, including inflammation, cancer, autoimmune disease, and vaccination

Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Assistant Professor
Research Areas:
Biomechanics, Nanotechnology, Pharmaceuticals & Drug Delivery
Professor
Research Interests:

We use light, neutrons, and molecular dynamics simulation to probe intramolecular and intermolecular motion on timescales ranging from MHz to PHz. These studies inform us about complex interactions between molecules and within molecular systems that underly macroscopic behaviors as disparate as materials properties and biological function.  Intra-molecular vibrations provide unique spectral “barcodes” for chemical substances. My group and I introduced broadband coherent anti-Stokes Raman scattering (BCARS) microscopy in 2004, which uses nonlinear light-matter interactions to rapidly read these spectra and generate sub-micron resolved images containing full Raman vibrational spectra at each pixel. We continue to improved BCARS imaging speed and sensitivity. Our current pixel acquisition time is a few milliseconds, providing an imaging speed that is conducive to practical materials and biological applications, and our work was recognized in 2014 as as one of the top 10 innovations in BioPhotonics. The goals in this project focus on instrument development and scientific discovery. Instrument development opportunities include innovations in ultrafast, nonlinear optics and computation (we envision microsecond spectral acquisition, requiring data processing and analysis at Gb/s rates). Opportunities for scientific discovery are wide-ranging. We currently focus on selected mechanistic questions in cancer biology, viral infection, and lipid metabolism, and on developing approaches for characterizing cell culture and biopharmaceutical formulation.  Microscopic inter-molecular motions underly many macroscopic properties of liquids and solids. We use light scattering, neutron scattering, and molecular dynamics simulation to characterize these motions in pursuit of a clear, molecularly-based understanding of how they ultimately lead to relaxation and transport in amorphous systems (liquids and glasses). We have shown that liquid dynamics on a 1 picosecond timescale are composed of two distinct types of motion. This finding has allowed us to derive simple expressions for molecular transport in liquids and amorphous solids based on easily measured or simulated picosecond dynamic quantities.  As we develop these insights, they will help materials scientists to reliably perform bottom-up design of novel materials with targeted transport and relaxation properties. Opportunities on this project include development of novel approaches to characterize these picosecond motions, refining and testing our ideas about liquid dynamics, and applying these ideas to solve problems in areas such as ionic liquids for battery applications, performance of drug eluting stents, and stabilizing freeze-dried vaccines and therapeutic proteins for use in developing nations.

Research Areas:
BioImaging, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Areas:
BioImaging, Nanotechnology, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Systems Biology, Tissue Engineering & Regenerative Medicine
Assistant Professor
Research Interests:

In the Dahlman Lab, we focus on the interface between nanotechology, molecular biology, and genomics. We design drug delivery vehicles that target RNA and other nucleic acids to cells in the body. We have delivered RNAs to endothelial cells, and have treated heart disease, cancer, inflammation, pulmonary hypertension, emphysema, and even vein graft disease. Because we can deliver RNAs to blood vessels at low doses, sometimes we decide to deliver multiple therapeutic RNAs to the same cell at once. These 'multigene therapies' have been used to treat heart disease and cancer. Why is this important? Most diseases are caused by combinations of genes, not a single gene. We also rationally design the nucleic acids we want to deliver. For example, we re-engineered the Cas9 sgRNA to turn on genes, instead of turning them off. This enabled us to easily turn on gene A and turn off gene B in the same cell.

Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Professor
Research Interests:

Bioengineering: lymphatics, lipid metabolism, biomechanics, biomedical optics, image processing, and tissue engineering.

Research Areas:
BioImaging, Biomaterials, Biomechanics, Nanotechnology, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Assistant Professor of Biomedical Engineering, Assistant Professor of Pediatrics
Research Interests:

The Dreaden Lab uses molecular engineering to impart augmented, amplified, or non-natural function to tumor therapies and immunotherapies. The overall goal of our research is to engineer molecular and nanoscale tools that can (i) improve our understanding of fundamental tumor biology and (ii) simultaneously serve as cancer therapies that are more tissue-exclusive and patient-personalized. The lab is housed on the Emory SOM campus and currently focuses on three main application areas: optically-triggered immunotherapies, combination therapies for pediatric cancers, and nanoscale cancer vaccines. Our work aims to translate these technologies into the clinic and beyond.

Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Associate Professor, Georgia Cancer Coalition Distinguished Scholar, Director, Quantitative BioImaging Laboratory (QBIL)
Research Areas:
Biomechanics, Nanotechnology, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery, Systems Biology
Professor,
Research Interests:

Dr. Jacob's research is directed at stress induced phase changes, nanoscale characterization of materials, synthesis of polymeric nanofibers, mechanical behavior of fiber assemblies (particularly related to biological systems and biomimitic systems), nanoparticle reinforced composites, transdermal drug delivery systems, large scale deformation of rubbery (networked) polymers, and nanoscale fracture of materials. The objectives in this work, using theoretical, computational and experimental techniques, is to understand the effect of micro- and nano- structures in the behavior of materials in order to try to design the micro/nano structures for specific materials response.

Research Areas:
Biomaterials, Biomechanics, Nanotechnology, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Interests:

Systems biophotonics: single-molecule biophotonics, super-resolution and advanced optical microscopy, imaging instrumentation and devices.

Research Areas:
BioImaging, Medical Robotics, Nanotechnology, Neuroengineering, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Interests:

Molecular engineering, nucleic acid self-assembly, nanomaterials, nanomedicne, and targeted imaging and delivery.

Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Associate Professor
Research Interests:

Microphysiological systems (Organ-on-a-Chip), Theranostic nanomaterials (Nanomedicine), Biomaterials, Microfluidics, Controls

Research Areas:
Biomaterials, Nanotechnology, Neuroengineering, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Associate Professor
Research Interests:

Cancer and DNA nanotechnology, engineering immunity, noninvasive diagnostics, nanomedicine, biomedical micro- and nanosystems, high throughput technologies. My research program is conducted at the interface of the life sciences, medicine and engineering where a central focus is understanding how to harness the sophisticated defense mechanisms of immune cells to eradicate disease and provide protective immunity. To aid in our studies, we use high-throughput technologies such as next-generation sequencing and quantitative mass spectrometry, and pioneer the development of micro- and nanotechnologies in order to achieve our goals. We focus on clinical problems in cancer, infectious diseases and autoimmunity, and ultimately strive to translate key findings into therapies for patients.

Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Associate Professor
Research Interests:

Bio-inspired colloidal assembly for multifunctional drug delivery vehicles and colloidal-based sensing.

Research Areas:
Biomaterials, Pharmaceuticals & Drug Delivery
Regents' Professor
Research Interests:

Drug, gene and vaccine delivery; transdermal delivery; ocular delivery; intracellular delivery; microneedles; microfabricated devices; ultrasound

Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Assistant Professor
Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Tissue Engineering & Regenerative Medicine
Assistant Professor
Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Systems Biology
Deputy Director, BioEngineering Graduate Program
Associate Professor
Research Interests:

Systems biology, bioinformatics, metabolism, and metabolomics.

Research Areas:
Pharmaceuticals & Drug Delivery, Systems Biology
Professor
Research Interests:

Bioengineering and Microelectromechanical Systems: Atomic force microscopy, pathogen adhesion and endocytosis, cell biomechanics, single molecule biophysics, drug delivery and targeting, cell membrane mimetics, and biosensors.

Research Areas:
BioImaging, Biomaterials, Biomechanics, Nanotechnology, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Carol Ann and David D. Flanagan Professor
Research Interests:

Development of novel polymeric biomaterials, regeneration of tendon/ligament, and protein delivery for orthopaedic tissue engineering.

Research Areas:
Biomaterials, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Tissue Engineering & Regenerative Medicine
Associate Professor
Research Areas:
Medical Robotics, Nanotechnology, Neuroengineering, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Tissue Engineering & Regenerative Medicine
Associate Professor
Research Interests:

My research interest is focused on using computer simulations of biological systems to understand and predict the human health effects of environmental and pharmaceutical perturbations. These perturbations, elicited by environmental chemicals, dietary supplements, and drugs, can alter the dynamics of the molecular circuits and networks operating in cells, leading to multiple disease endpoints. In close collaboration with experimental biologists and toxicologists, I develop mechanistically based computational systems biology models of cellular biochemical pathways and organism-level control systems.

Research Areas:
Pharmaceuticals & Drug Delivery, Systems Biology
Research Interests:

Hello I'm Philip, and I'm currently working for the IEN as the Biocleanroom Lab Manager, and Processing Engineer supporting the Integrated 3D systems Lab (Bakir) In my studies I'm pursuing a non-thesis BioE Masters Degree. Feel free to contact me about the Biocleanroom, BioE, or getting trained on tools in the Marcus Cleanrooms.

Research Areas:
Biomaterials, Nanotechnology, Neuroengineering, Pharmaceuticals & Drug Delivery
Research Areas:
Pharmaceuticals & Drug Delivery
BioEngineering
Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Research Interests:

Retinal research, tissue regeneration

Research Areas:
Biomaterials, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Research Interests:

Molecular Immunology;  Mechanobiology of T-cell receptor and Programmed cell death 1; Molecular dynamics simulations.

Research Areas:
Nanotechnology, Biomechanics, Pharmaceuticals & Drug Delivery
Bioengineering
Research Areas:
Biomaterials, Biomechanics, Nanotechnology, Pharmaceuticals & Drug Delivery
Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery, Biomaterials
Research Areas:
Biomaterials, Neuroengineering, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Tissue Engineering & Regenerative Medicine
Research Areas:
Biomaterials, Pharmaceuticals & Drug Delivery
Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery
Research Areas:
Pharmaceuticals & Drug Delivery
Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery, Biomaterials
Research Interests:

Engineering self-assembled protein vesicles for therapeutics.

Research Areas:
Biomaterials, Pharmaceuticals & Drug Delivery
Research Areas:
Tissue Engineering & Regenerative Medicine, Pharmaceuticals & Drug Delivery, Biomaterials
Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Research Interests:

Systems Biology Computational Modeling, Personalized Medicine, Immunotherapeutics

Research Areas:
Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Tissue Engineering & Regenerative Medicine
Research Areas:
Pharmaceuticals & Drug Delivery
ACS Bridge
Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery
Research Areas:
Biomaterials, Nanotechnology, Pharmaceuticals & Drug Delivery, Systems Biology
Bioengineering
Research Interests:

Immunology, organ-on-chip, immunotherapies

Research Areas:
Biomaterials, Pharmaceuticals & Drug Delivery, Tissue Engineering & Regenerative Medicine
Research Interests:

In-vitro models of disease

Research Areas:
BioImaging, Tissue Engineering & Regenerative Medicine, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Biomaterials
Research Areas:
Tissue Engineering & Regenerative Medicine, Neuroengineering, Pharmaceuticals & Drug Delivery
Research Interests:

Lymphoma, microfluidics, cancer immunotherapy 

Research Areas:
Pharmaceuticals & Drug Delivery, Biomaterials
Research Interests:

Cellular Engineering

Research Areas:
Systems Biology, Nanotechnology, Biomechanics, Pharmaceuticals & Drug Delivery
Research Interests:

Biomaterials, Immunology, Tissue Engineering, Polymers

Research Areas:
Tissue Engineering & Regenerative Medicine, Pharmaceuticals & Drug Delivery, Biomaterials
Bioengineering(Mechanical Engineering)
Research Interests:

Microphysiological System, Drug Delivery, Microfluidic

Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery, Systems Biology
Research Areas:
Biomechanics, Pharmaceuticals & Drug Delivery
Ph.D. Student + R&D Engineer
Research Interests:

Neural Engineering + Biomaterials

Research Areas:
BioImaging, Medical Robotics, Tissue Engineering & Regenerative Medicine, Nanotechnology, Biomechanics, Neuroengineering, Pharmaceuticals & Drug Delivery, Stem Cell Engineering, Biomaterials
Research Interests:

Cancer Microenvironment and Metastasis, Effect of Mechanical Forces on Biological Systems, Vascular Permeability

Research Areas:
Nanotechnology, Pharmaceuticals & Drug Delivery, Biomaterials