BioE PhD Defense - Venu Ganti

Advisor:
Omer T. Inan, PhD (Georgia Institute of Technology)

 
Committee:
David Frakes, PhD (Georgia Institute of Technology)
Rishikesan Kamaleswaran, PhD (Georgia Institute of Technology)
Jin-Oh Hahn, PhD (University of Maryland, College Park)
Animesh Tandon, MD (Cleveland Clinic Children's Hospital)
 

Enabling Wearable Hemodynamic Monitoring using Multimodal Cardiomechanical Sensing Systems

Biomarkers such as blood pressure and stroke volume are instrumental to understanding the pathogenesis of cardiovascular disease. Unfortunately, the monitoring of these hemodynamic parameters is still tethered to in-clinic measurements or is too unaccommodating and inconvenient for ubiquitous use. To address this gap, in this work, we explore seismocardiogram-based wearable multimodal sensing techniques to estimate and enable the use of digital biomarkers—in particular, blood pressure and stroke volume. First, the performance of a multimodal, wrist-worn device capable of obtaining noninvasive pulse transit time measurements is used to estimate blood pressure in an unsupervised, at-home setting. Second, the feasibility of this wrist-worn device is comprehensively evaluated in a diverse and medically underserved population over the course of several perturbations used to modulate blood pressure through different pathways. Finally, the ability of wearable signals—acquired from a custom chest-worn biosensor—to noninvasively quantify stroke volume in patients with congenital heart disease is examined in a hospital setting. Collectively, this work demonstrates the advancements necessary towards enabling noninvasive, longitudinal, and accurate measurements of these biomarkers in remote settings, which offers to advance health equity and disease monitoring in low-resource settings.