- Characterization of the blood vessel wall's deformity in diseased states and how this impacts both surgical and endovascular therapies
- Improvement of the angiogenic capacity of adipose-tissue derived mesenchymal stem cells for the purpose of saving ischemic limbs
- Development of therapeutics to restore function and arterial hysteresis to patients with peripheral arterial disease using in vivo and ex vivo systems
Dr. Brewster's clinical practice is focused on general vascular surgery and peripheral arterial disease with a clinical research interest in the use of ultrasound to diagnose and treat vascular disease, the patient and surgeon perspective in surgical decision-making, selection and outcomes of carotid artery stenosis therapy, and optimal therapy for limb salvage. His lab is investigating the biomechanical mechanisms that contribute to pathologic arterial remodeling in peripheral arterial disease, developing regenerative strategies for use in ischemic tissue, and working to improve the function of patients who have undergone major amputation.
Through his joint affiliations with the Atlanta Clinical and Translational Science Institute and the Wallace Coulter Department of Biomedical Engineering at Georgia Tech/Emory, Dr. Brewster has access to an exceptional pool of collaborators, and has received a steady stream of various federal, foundation, and industry grants. His recent studies have included investigations of the molecular process of disturbed flow in arterial stiffening and evaluations of types of medical imaging as decision support tools in assessing fibrosis and sarcopenia in combat casualty amputees.